Ring Expansion Magic 16 to 33 Membered Macrocyclic Lactones! #sciencefa...
Macrocyclic lactones, particularly those ranging from 16 to 33 members, play a crucial role in medicinal and organic chemistry due to their unique structural and functional properties. Ring expansion strategies offer an efficient approach to synthesizing these large macrocycles, enabling access to complex natural products and bioactive compounds. These expanded lactones exhibit remarkable biological activities, including antibacterial, antifungal, and anticancer properties, making them valuable in drug discovery and pharmaceutical applications. The development of innovative synthetic methods, such as ring-closing metathesis, biomimetic cyclization, and cascade reactions, has significantly advanced the field, allowing for the efficient construction of these intricate molecular architectures. As a result, ring expansion remains a powerful tool in modern organic synthesis, driving progress in natural product synthesis and medicinal chemistry. #MacrocyclicLactones #OrganicChemistry #Ri...