Sciencefather | Molecular Biology of Cholangiocarcinoma #Sciencefather #...

Cholangiocarcinoma (CCA) is a malignant tumor originating in the bile duct epithelium. Its molecular biology reveals a complex interplay of genetic, epigenetic, and environmental factors contributing to its pathogenesis. Key genetic alterations include mutations in IDH1/2, FGFR2 fusions, and KRAS mutations, which drive oncogenesis. Epigenetic changes, such as DNA methylation and histone modifications, further influence gene expression and tumor behavior. Chronic inflammation due to liver fluke infections, primary sclerosing cholangitis, or hepatitis B and C infections significantly increases the risk of CCA. Additionally, dysregulation of signaling pathways, including Notch, Wnt/β-catenin, and PI3K/AKT/mTOR, plays a crucial role in tumor progression and resistance to therapy. Understanding these molecular mechanisms is essential for developing targeted therapies and improving patient outcomes in cholangiocarcinoma. #Sciencefather #Genetics #Biostatistician #Epigenetics #CancerBiology #Oncogenesis #DNA #RNA #Proteomics #Genomics #CellBiology #Microbiology #Biochemistry #Bioinformatics #GeneticEngineering #CRISPR #GeneExpression #CellSignaling #TumorBiology #Cholangiocarcinoma #CancerResearch #MolecularGenetics #GeneticMutations #Pathogenesis #Biotech #ResearchScience Website: awardandhonors.com For Enquiries : support@awardandhonors.com Award Nomination : x-i.me/UOee Award Registration : x-i.me/awdreg24 Get Connected Here : ------------------------------------------ Facebook: www.facebook.com/profile.php?... Instagram: www.instagram.com/victoriareg... Twitter: twitter.com/VictoriRegina11 Pintrest: pinterest.com/awardandhonor/

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